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Drug Interactions between givinostat and romidepsin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

romiDEPsin givinostat

Applies to: romidepsin and givinostat

Using givinostat together with romiDEPsin may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which may result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting, which are commonly reported as side effects of givinostat treatment). Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring of your electrocardiogram to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

givinostat food

Applies to: givinostat

Food increases the absorption of givinostat. To ensure adequate blood levels of the medication, givinostat should be administered with food. Additionally, food can help mask the bitter taste of the oral suspension. Follow up with your healthcare professional if you have any additional questions.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Histone deacetylase inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'histone deacetylase inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'histone deacetylase inhibitors' category:

  • givinostat
  • romidepsin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer