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Drug Interactions between givinostat and lomefloxacin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

lomefloxacin givinostat

Applies to: lomefloxacin and givinostat

Using givinostat together with lomefloxacin may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which may result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting, which are commonly reported as side effects of givinostat treatment). Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring of your electrocardiogram to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

givinostat food

Applies to: givinostat

Food increases the absorption of givinostat. To ensure adequate blood levels of the medication, givinostat should be administered with food. Additionally, food can help mask the bitter taste of the oral suspension. Follow up with your healthcare professional if you have any additional questions.

Moderate

lomefloxacin food

Applies to: lomefloxacin

Lomefloxacin and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of lomefloxacin into the bloodstream and reduce its effectiveness. If possible, it may be best to avoid taking multivitamin with minerals while you are being treated with lomefloxacin. Otherwise, lomefloxacin should be taken 2 to 4 hours before or 4 to 6 hours after a multivitamin with minerals dose, lomefloxacin should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or lomefloxacin and multivitamin with minerals should be taken as directed by your healthcare provider. Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer