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Drug Interactions between gepirone and Rapamune

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sirolimus gepirone

Applies to: Rapamune (sirolimus) and gepirone

Using sirolimus together with gepirone may increase the blood levels and effects of one or both medications. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

sirolimus food

Applies to: Rapamune (sirolimus)

Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.

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Moderate

gepirone food

Applies to: gepirone

Food helps with the absorption of gepirone into the blood stream. You should take this medication with food at about the same time every day. You should not consume grapefruit or grapefruit products while taking this medication as they can increase the blood levels of gepirone in your body, putting you at a higher risk of serious side effects like serotonin syndrome or a change in the electrical activity of your heart called QT prolongation. Seek immediate medical attention if you experience any of the following signs or symptoms of these potentially life-threatening side effects: irregular or fast heartbeat, dizziness, lightheadedness, fainting, agitation, confusion, sweating, flushing, changes in blood pressure, seizures, hallucinations, or a loss of coordination. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer