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Drug Interactions between Genaton Chewable and Thera-D Rapid Repletion

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

aluminum hydroxide cholecalciferol

Applies to: Genaton Chewable (alginic acid / aluminum hydroxide / magnesium trisilicate) and Thera-D Rapid Repletion (cholecalciferol)

Chronic use of aluminum hydroxide or other medications that contain aluminum may cause toxicity in patients with advanced kidney disease due to impaired ability to clear aluminum from the body. Aluminum can accumulate and deposit in various tissues over time, causing toxicities such as weak bones, fractures, bone pain, muscle weakness, anemia, mental changes, seizures, dementia, and coma. The risk of aluminum toxicity may be further increased during treatment with vitamin D or vitamin D analogs like cholecalciferol, which increase the absorption of aluminum from the intestine. You should avoid taking medications that contain aluminum unless otherwise directed by your doctor. Always check the labels of over-the-counter medications to be sure they do not contain aluminum before you use them. Talk to your doctor or other healthcare professional if you are not sure whether a product contains aluminum. They may also be able to suggest alternative medications when necessary. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

cholecalciferol magnesium trisilicate

Applies to: Thera-D Rapid Repletion (cholecalciferol) and Genaton Chewable (alginic acid / aluminum hydroxide / magnesium trisilicate)

Using cholecalciferol together with magnesium trisilicate can lead to elevated magnesium blood levels, particularly in individuals with reduced kidney function. Symptoms of high magnesium levels may include nausea, vomiting, flushing, drowsiness, dizziness, confusion, muscle weakness, reduced reflexes, low blood pressure, slow heart rate, and impaired breathing. You should seek medical attention if you experience these symptoms. If you are on dialysis and treated with cholecalciferol or other vitamin D medications, you should generally avoid taking products that contain magnesium without first talking to your doctor, as high levels of magnesium over time can lead to bone problems. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

aluminum hydroxide food

Applies to: Genaton Chewable (alginic acid / aluminum hydroxide / magnesium trisilicate)

Citrate, or citric acid, can increase the absorption of aluminum hydroxide. This may lead to elevated blood levels of aluminum, particularly in individuals with reduced kidney function, since aluminum is primarily eliminated by the kidneys. Excess aluminum may deposit and cause problems in various tissues including bone, brain, heart, liver, muscles, and spleen. Over time, weak bones, bone pain, fractures, skeletal deformity, brain disorders, and anemia may develop. Talk to your doctor before using aluminum hydroxide if you have kidney impairment or are on hemodialysis. You should avoid or limit the consumption of citrate-containing foods and beverages (e.G., soft drinks, citrus fruits, fruit juices) during treatment with aluminum hydroxide. Be aware that some effervescent and dispersible drug formulations may also contain citrate and should be restricted as well. Even if you do not have kidney problems, it may be best to separate the dosing of aluminum hydroxide and citrate-containing products by 2 to 3 hours. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

When aluminum hydroxide is taken during enteral nutrition therapy (tube feeding), the tube may get clogged. Therefore, aluminum hydroxide should not be mixed with or given after high-protein tube feedings. The dose should be separated from the feeding by as much as possible, and the tube should be thoroughly flushed before administration of the dose.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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