Drug Interactions between gemfibrozil and rosiglitazone

Talk to your doctor before using rosiglitazone together with gemfibrozil. Combining these medications may significantly increase the blood levels of rosiglitazone. You may be more likely to experience side effects such as hypoglycemia, or low blood sugar, that can sometimes occur with the use of rosiglitazone. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and palpitation. The risk of other serious but uncommon side effects such as fluid retention, macular edema (swelling in the back of the eye), new or worsening heart failure, heart attack, bone fractures, anemia, and liver problems may also be increased. You may need a dose adjustment or more frequent monitoring of your blood sugar and other tests to safely use both medications. Contact your doctor immediately if you experience sudden lightheadedness; nausea or vomiting; blurred vision or other visual abnormalities; excessive or rapid weight gain; swelling in the ankles or legs; shortness of breath or difficulty breathing; unusual tiredness; chest pain or tightness; or pain in the arms, back, neck, jaw or stomach. You should also seek prompt medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.