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Drug Interactions between fruquintinib and Nallpen

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nafcillin fruquintinib

Applies to: Nallpen (nafcillin) and fruquintinib

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with moderate inducers of CYP450 3A4 may decrease the plasma concentrations of fruquintinib, which is primarily metabolized by the isoenzyme. Concomitant use with efavirenz, a moderate CYP450 3A4 inducer, decreased fruquintinib peak plasma concentration (Cmax) and systemic exposure (AUC) by 4% and 32%, respectively. Reduced efficacy of fruquintinib may occur.

MANAGEMENT: Coadministration of fruquintinib with moderate CYP450 3A4 inducers should generally be avoided. The potential for diminished pharmacologic effects of fruquintinib should be considered during coadministration with moderate CYP450 3A4 inducers. However, if concomitant use is required, the manufacturer advises that fruquintinib may be continued at the recommended dosage.

References

  1. "Product Information. Fruzaqla (fruquintinib)." Takeda Pharmaceuticals America (2023):

Drug and food interactions

Moderate

nafcillin food

Applies to: Nallpen (nafcillin)

You may experience reduced absorption of nafcillin in the presence of food. The effectiveness of the antibiotic may be reduced. Nafcillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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