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Drug Interactions between foscarbidopa / foslevodopa and mephentermine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

mephentermine foslevodopa

Applies to: mephentermine and foscarbidopa / foslevodopa

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with foslevodopa may potentiate the cardiovascular effects of sympathomimetic agents (e.g., epinephrine, norepinephrine, isoproterenol, amphetamine). Additive increases in blood pressure and heart rate may occur due to enhanced sympathetic activity. However, data evaluating the interaction are not available.

MANAGEMENT: The use of levodopa with sympathomimetic agents should generally be avoided. If concomitant use is required, close monitoring of the cardiovascular system is recommended. Some authorities consider the coadministration of sympathomimetic agents and foslevodopa to be contraindicated (Canada).

Drug and food interactions

Moderate

foslevodopa food

Applies to: foscarbidopa / foslevodopa

Alcohol can increase the nervous system side effects of foslevodopa such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with foslevodopa. You may experience reduced effectiveness of foslevodopa in the presence of foods or enteral (tube) feedings with a high protein content. This may make the symptoms of Parkinson's disease worse. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Contact your doctor if your condition changes.

Moderate

mephentermine food

Applies to: mephentermine

Both mephentermine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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