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Drug Interactions between fluconazole and piroxicam

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fluconazole piroxicam

Applies to: fluconazole and piroxicam

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with fluconazole may alter the plasma concentrations of naproxen and its pharmacologically active metabolite. The proposed mechanism is the fluconazole mediated inhibition of the metabolism of naproxen via CYP450 2C9. The interaction may extend to other nonsteroidal anti-inflammatory drugs (NSAIDs) such as meloxicam, lornoxicam, and diclofenac. However, clinical data evaluating this interaction for all the abovementioned nonsteroidal anti-inflammatory drugs are not available.

MANAGEMENT: Caution is recommended with the concomitant use of NSAIDs with fluconazole. It may be advisable to monitor the pharmacologic response to the NSAID and its adverse effects more closely whenever fluconazole is added to or withdrawn from therapy. Patients should be advised to report possible signs of NSAID-related toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools.

Drug and food/lifestyle interactions

Moderate

piroxicam food/lifestyle

Applies to: piroxicam

Ask your doctor before using piroxicam together with ethanol (alcohol). Do not drink alcohol while taking piroxicam. Alcohol can increase your risk of stomach bleeding caused by piroxicam. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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