Drug Interactions between fingolimod and teriflunomide

Talk to your doctor before using fingolimod together with teriflunomide. Combining these medications can increase the risk of serious infections. Rarely, these medications may also cause liver damage. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Because these drugs can stay in your blood for prolonged periods after the last dose (up to 2 months for fingolimod and 2 years for teriflunomide), interactions can occur even if you have stopped taking one medication and are starting the other. Contact your doctor immediately if you develop fever or other signs of infection during treatment with these medications, whether together or alone. You should also seek immediate medical attention if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.