Drug Interactions between fingolimod and ruxolitinib topical

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration of topical ruxolitinib with other Janus Kinase (JAK) inhibitors, biologic immunomodulators, or other potent immunosuppressants (e.g., cyclosporine, azathioprine) may potentiate the risk of infections as well lymphoma and other malignancies. Serious and sometimes fatal infections including bacterial, mycobacterial (e.g., tuberculosis), fungal, viral including viral reactivation, and other opportunistic infections have been reported in patients who have received oral ruxolitinib, including oral ruxolitinib for inflammatory conditions.

MANAGEMENT: The safety and efficacy of topical ruxolitinib in combination with immunosuppressive agents has not been evaluated. It is recommended that the concomitant use of topical ruxolitinib with other Janus Kinase (JAK) inhibitors, biologic immunomodulators, or other potent immunosuppressants (e.g., cyclosporine, azathioprine) should be avoided. Patients receiving topical ruxolitinib should be closely monitored for the development of signs and symptoms of infection during and after treatment, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy. If a patient develops a serious infection, ruxolitinib topical therapy should be interrupted until the infection is controlled.