Drug Interactions between finerenone and vericiguat

Finerenone may be taken with or without food. However, you should avoid grapefruit and grapefruit juice during treatment with this medication. Grapefruit juice may significantly increase the blood levels and effects of finerenone. This can increase the risk of developing hyperkalemia, or high levels of potassium in the blood, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia during treatment with finerenone if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. You should also avoid potassium-containing salt substitutes or over-the-counter potassium supplements during treatment with finerenone unless otherwise directed by your doctor. Seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly enhances the absorption of vericiguat. You should take each dose of vericiguat at the same time each day with food. If you receive enteral nutrition (tube feeding), take vericiguat with your feeding. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor if you have questions or have difficulty taking vericiguat with food. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.