Skip to main content

Drug Interactions between Filspari and ripretinib

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

ripretinib sparsentan

Applies to: ripretinib and Filspari (sparsentan)

Sparsentan may increase the blood levels of ripretinib in some patients. This may increase the risk and/or severity of side effects such as nausea, vomiting, constipation, diarrhea, hair loss, muscle pain, high blood pressure, heart failure, skin reactions, and skin cancers. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know if you develop redness, pain, blisters, rash, bleeding, or swelling on the palms of your hands or soles of your feet, as these may be signs and symptoms of a potentially severe and painful condition known as Palmar-Plantar Erythrodysesthesia Syndrome (PPES), or hand-foot syndrome. Also seek medical attention if you experience signs and symptoms of heart failure such as fatigue, shortness of breath, protruding neck veins, water retention, and swelling in the abdomen, legs or ankles. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions

Major

sparsentan food

Applies to: Filspari (sparsentan)

If you are taking sparsentan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. This can cause high levels of potassium in your blood. High levels of potassium can cause weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Call your doctor at once if you have any of these symptoms.

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with sparsentan as they may increase the blood levels of sparsentan. This may increase the risk of side effects such as hepatotoxicity, acute kidney injury, hyperkalemia, edema, and hypotension.

Swallow sparsentan whole with water before your morning or evening meal. Take your dose with the same meal each day. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

ripretinib food

Applies to: ripretinib

Grapefruit juice may increase the blood levels of certain medications such as ripretinib. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with ripretinib. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer