Can you take Ferrous sulfate/folic acid with Iron Sulfate?
No drug interactions found, but 9 warnings to review for the following 2 drugs:
- ferrous sulfate/folic acid
- Iron Sulfate (ferrous sulfate)
Drug interactions
There were no interactions found between ferrous sulfate/folic acid and Iron Sulfate. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition.
It can be intentional, when combining drugs with similar actions adds demonstrated therapeutic benefit — or unintentional, such as when a patient sees multiple prescribers or fills prescriptions at more than one pharmacy, which can lead to adverse effects.
Duplication:
Iron preparations
The recommended maximum number of medicines in the 'iron preparations' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'iron preparations' category:
- ferrous sulfate/folic acid
- Iron Sulfate (ferrous sulfate)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
folic acid Food/Lifestyle
Applies to: ferrous sulfate/folic acid
Talk to your doctor before using alcohol together with folic acid. Excessive consumption of alcohol may reduce the absorption and increase the elimination of folic acid. Contact your doctor if your symptoms worsen or your condition changes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate:
ferrous sulfate Food/Lifestyle
Applies to: ferrous sulfate/folic acid and Iron Sulfate (ferrous sulfate)
Food may reduce the absorption and blood levels of ferrous sulfate. In addition, some oral medications can also interfere with ferrous sulfate absorption into the bloodstream, which may make the medication less effective in treating your condition. Likewise, ferrous sulfate may interfere with the absorption of other orally administered medications. You should take ferrous sulfate on an empty stomach at least one hour before or two hours after a meal. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Talk to your doctor or pharmacist if you have questions about how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactions Applies to: 6 conditions, including Peptic Ulcer, Noninfectious Colitis, Anemia of Unspecified Nutritional Deficiency, Blood Transfusion, and Achlorhydria.
Achlorhydria
Moderate:
ferrous sulfate/folic acid, Iron Sulfate
The ferrous sulfate in ferrous sulfate/folic acid and Iron Sulfate has a moderate potential interaction with Achlorhydria.
Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.
Anemia of Unspecified Nutritional Deficiency
Major:
ferrous sulfate/folic acid
The folic acid in ferrous sulfate/folic acid has a major potential interaction with Anemia of Unspecified Nutritional Deficiency.
The use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
Blood Transfusion
Major:
ferrous sulfate/folic acid, Iron Sulfate
The ferrous sulfate in ferrous sulfate/folic acid and Iron Sulfate has a major potential interaction with Blood Transfusion.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Hemoglobinopathy
Major:
ferrous sulfate/folic acid, Iron Sulfate
The ferrous sulfate in ferrous sulfate/folic acid and Iron Sulfate has a major potential interaction with Hemoglobinopathy.
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
Noninfectious Colitis
Moderate:
ferrous sulfate/folic acid, Iron Sulfate
The ferrous sulfate in ferrous sulfate/folic acid and Iron Sulfate has a moderate potential interaction with Noninfectious Colitis.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
Peptic Ulcer
Moderate:
ferrous sulfate/folic acid, Iron Sulfate
The ferrous sulfate in ferrous sulfate/folic acid and Iron Sulfate has a moderate potential interaction with Peptic Ulcer.
Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.
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ferrous sulfate/folic acid
A total of 122 drugs are known to interact with ferrous sulfate/folic acid.
- Ferrous sulfate/folic acid is in the following drug classes: iron products, vitamin and mineral combinations.
- Ferrous sulfate/folic acid is used to treat Iron Deficiency Anemia.
Iron Sulfate
A total of 89 drugs are known to interact with Iron Sulfate.
- Iron sulfate is in the drug class iron products.
- Iron sulfate is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.