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Drug Interactions between fenfluramine and Lonsurf

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

fenfluramine tipiracil

Applies to: fenfluramine and Lonsurf (tipiracil / trifluridine)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with fenfluramine may increase the plasma concentrations of drugs that are substrates of the multidrug and toxin extrusion 1 (MATE-1) efflux transporter. Fenfluramine is an inhibitor of the MATE-1 efflux transporter in vitro. However, clinical data are not available.

MANAGEMENT: Until more information is available, caution is advised when fenfluramine is coadministered with drugs that are substrates of the multidrug and toxin extrusion 1 (MATE-1) efflux transporter, particularly those with a narrow therapeutic range. If coadministration is required, clinical and laboratory monitoring for drug-related toxicities should be considered and the dosage adjusted as necessary in accordance with the product labeling of the coadministered drug.

Drug and food interactions

Moderate

fenfluramine food

Applies to: fenfluramine

Using fenfluramine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. In addition, you may also be more likely to experience nervous system side effects such as dizziness, drowsiness, depression, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with fenfluramine. Do not use more than the recommended dose of fenfluramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

Moderate

trifluridine food

Applies to: Lonsurf (tipiracil / trifluridine)

Trifluridine should be taken within one hour after eating your morning or evening meals. This may help to reduce the medication's harmful effects on white blood cells. Talk to you doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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