Drug Interactions between Exforge HCT and lurbinectedin
This report displays the potential drug interactions for the following 2 drugs:
- Exforge HCT (amlodipine/hydrochlorothiazide/valsartan)
- lurbinectedin
Interactions between your drugs
amLODIPine lurbinectedin
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan) and lurbinectedin
AmLODIPine may increase the blood levels of lurbinectedin. This may increase side effects such as liver problems and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should seek medical attention if you develop paleness, fatigue, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, pain or burning during urination, nausea or vomiting, or pain on the right side of the abdomen. Talk to your doctor if you have any questions or concerns. You may need more frequent monitoring to safely use both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
hydroCHLOROthiazide amLODIPine
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan) and Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
Information for this minor interaction is available on the professional version.
Drug and food interactions
lurbinectedin food
Applies to: lurbinectedin
Do not consume Seville oranges, grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lurbinectedin unless directed otherwise by your doctor. Grapefruit and Seville oranges may increase the blood levels of lurbinectedin. This may increase side effects such as liver problems and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
valsartan food
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
If you are taking valsartan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. This can cause high levels of potassium in your blood. High levels of potassium can cause weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Call your doctor at once if you have any of these symptoms.
hydroCHLOROthiazide food
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
HydroCHLOROthiazide and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
amLODIPine food
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
AmLODIPine and ethanol (alcohol) may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
amLODIPine food
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
Using amLODIPine together with multivitamin with minerals can decrease the effects of amLODIPine. Talk with your doctor before using amLODIPine and multivitamin with minerals together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
amLODIPine food
Applies to: Exforge HCT (amlodipine / hydrochlorothiazide / valsartan)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.