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Drug interactions between etretinate and isotretinoin

Results for the following 2 drugs:
etretinate
isotretinoin

Interactions between your drugs

Major

isotretinoin ↔ etretinate

Applies to:isotretinoin and etretinate

Using ISOtretinoin together with etretinate is generally not recommended. Combining these medications may increase the risk of hypervitaminosis A, a condition that stems from excessive vitamin A-related effects. Potentially serious problems that could occur include vision impairment, increased pressure in the brain, high cholesterol/triglycerides, and inflammation of the liver, pancreas, or the rest of the digestive tract. Check your food and medicine labels to make sure you do not consume additional vitamin A in excess of the recommended daily allowance. Talk to your doctor or pharmacist if you are uncertain whether you are getting too much vitamin A. Early signs and symptoms of hypervitaminosis A include inflammation or bleeding of the gums or lips; dry, scaly, itchy, or red skin; hair loss; headache; dizziness; and nausea. You should seek immediate medical attention if you experience potential signs that could indicate increased pressure in the brain (headache, nausea, vomiting, visual disturbances) or liver damage (fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, yellowing of the skin or eyes). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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