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Drug Interactions between estradiol and Intrarosa

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs


estradiol dehydroepiandrosterone (prasterone)

Applies to: estradiol and Intrarosa (dehydroepiandrosterone)

Dehydroepiandrosterone (prasterone) is a hormone that occurs naturally in your body and can be broken down to create the sex steroids testosterone (androgen) and estradiol (estrogen). Using dehydroepiandrosterone (prasterone) together with other sex steroid containing products such as estradiol may lead to an increase in side effects. The risk of this interaction might be reduced when one medication is administered topically or vaginally as less of the sex steroids are expected to reach your blood stream. Some of the more serious side effects of these types of therapies include blood clots (chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; trouble speaking or swallowing); cancer (breast, ovarian, prostate); gallbladder problems (pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; fever; bloating; upset stomach or vomiting); high blood pressure; liver problems (dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, vomiting, yellow skin or eyes); stroke (weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on 1 side of the face, blurred eyesight); mood changes; and memory problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


estradiol food

Applies to: estradiol

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.