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Drug Interactions between estradiol / norethindrone topical and rifapentine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

estradiol topical rifapentine

Applies to: estradiol / norethindrone topical and rifapentine

Rifapentine may reduce the blood levels and effects of estradiol topical. If you are using estradiol topical for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take estradiol topical for another purpose, such as hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

rifapentine norethindrone topical

Applies to: rifapentine and estradiol / norethindrone topical

Rifapentine may reduce the blood levels and effects of norethindrone topical. If you are using norethindrone topical for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take norethindrone topical for another purpose, such as hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

rifapentine food

Applies to: rifapentine

Food enhances the absorption of rifapentine and may reduce the incidence of stomach upset, nausea, and/or vomiting. However, if rifapentine is part of a combination product, the recommendations may differ. Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.