Drug Interactions between estradiol / norethindrone / relugolix and ethinyl estradiol
This report displays the potential drug interactions for the following 2 drugs:
- estradiol/norethindrone/relugolix
- ethinyl estradiol
Interactions between your drugs
ethinyl estradiol relugolix
Applies to: ethinyl estradiol and estradiol / norethindrone / relugolix
The following interaction applies only to women taking relugolix/estradiol/norethindrone (brand name Myfembree).
Using relugolix with other estrogen-containing medications for birth control such as ethinyl estradiol may reduce the effectiveness of relugolix in treating your condition. If you require contraception, it is recommended that you use a non-hormonal form of contraception during treatment with relugolix and for at least one week after its discontinuation to avoid unintended pregnancy. This is particularly important because relugolix may cause harm in the unborn child. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. In addition, using Myfembree may increase the risk of side effects from ethinyl estradiol, such as abdominal pain, blood clots, breast tenderness, breast pain, headache, and swelling of the hands, ankles or feet. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
norethindrone food
Applies to: estradiol / norethindrone / relugolix
Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norethindrone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.
ethinyl estradiol food
Applies to: ethinyl estradiol
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.
MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.
ethinyl estradiol food
Applies to: ethinyl estradiol
Information for this minor interaction is available on the professional version.
estradiol food
Applies to: estradiol / norethindrone / relugolix
Information for this minor interaction is available on the professional version.
ethinyl estradiol food
Applies to: ethinyl estradiol
Information for this minor interaction is available on the professional version.
norethindrone food
Applies to: estradiol / norethindrone / relugolix
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Estrogens
Therapeutic duplication
The recommended maximum number of medicines in the 'estrogens' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'estrogens' category:
- estradiol/norethindrone/relugolix
- ethinyl estradiol
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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