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Drug interactions between Esbriet and Ofev

Results for the following 2 drugs:
Esbriet (pirfenidone)
Ofev (nintedanib)

Interactions between your drugs

There were no interactions found in our database between Esbriet and Ofev - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Esbriet

A total of 116 drugs (590 brand and generic names) are known to interact with Esbriet.

Ofev

A total of 185 drugs (690 brand and generic names) are known to interact with Ofev.

Drug and food interactions

Moderate

pirfenidone food

Applies to: Esbriet (pirfenidone)

Pirfenidone should be taken with food to help reduce dizziness and gastrointestinal side effects such as diarrhea, nausea, vomiting, and upset stomach. Avoid smoking during treatment, as cigarette smoking can reduce the blood levels and effects of pirfenidone. If you are a smoker, you should try to quit smoking before starting treatment. Talk to your doctor or pharmacist if you have any questions or concerns, or need help in finding a smoking cessation program. You should also avoid consuming grapefruit or grapefruit juice while taking pirfenidone, as it may increase blood levels of the medication and lead to more side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

nintedanib food

Applies to: Ofev (nintedanib)

Food may help the absorption of nintedanib. You should take this medication with food and swallow it whole with liquid. Chewing or crushing the medication can leave a bitter taste.

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Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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