Drug Interactions between Epysqli and iptacopan
This report displays the potential drug interactions for the following 2 drugs:
- Epysqli (eculizumab)
- iptacopan
Interactions between your drugs
eculizumab iptacopan
Applies to: Epysqli (eculizumab) and iptacopan
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Concomitant use of iptacopan with other complement inhibitor therapies indicated for the treatment of paroxysmal nocturnal hemoglobinuria may increase the risk of additive adverse effects. These include serious, life-threatening, or fatal infections caused by encapsulated bacteria, decreased platelet counts, and increased blood pressure and cholesterol. Iptacopan is an oral proximal complement inhibitor that targets factor B of the alternative pathway of the complement cascade, while other complement inhibitors such as ravulizumab and eculizumab are intravenously administered terminal complement inhibitors that bind to the complement protein C 5 with high affinity. The primary safety and efficacy data for iptacopan was reported in two phase 3, open label trials. In both trials, iptacopan was administered as monotherapy, either in patients who had previously received anti-C5 treatment (APPLY-PNH) or in those who had not previously been treated with complement inhibitors (APPOINT-PNH). However, one multicenter, open-label, single-arm phase 2 trial (n=10) involved iptacopan given orally at 200 mg twice daily as an add-on therapy in patients already receiving eculizumab treatment reported no deaths or treatment-related serious adverse events during the study period.
MANAGEMENT: Concomitant use of iptacopan with complement inhibitors used in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) including eculizumab and ravulizumab, should generally be avoided. According to some authorities the combination of iptacopan with other complement inhibitor therapies for PNH is considered contraindicated, unless medically justified. The manufacturer's product information for these medicines should be consulted for dosage and timing recommendations when switching from one therapy to the other.
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Immunosuppressants for pnh
Therapeutic duplication
The recommended maximum number of medicines in the 'immunosuppressants for PNH' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'immunosuppressants for PNH' category:
- Epysqli (eculizumab)
- iptacopan
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.