Drug Interactions between Envarsus XR and Vimovo
This report displays the potential drug interactions for the following 2 drugs:
- Envarsus XR (tacrolimus)
- Vimovo (esomeprazole/naproxen)
Interactions between your drugs
naproxen tacrolimus
Applies to: Vimovo (esomeprazole / naproxen) and Envarsus XR (tacrolimus)
Tacrolimus may cause kidney problems, and combining it with other medications that can also affect the kidney such as naproxen may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
tacrolimus esomeprazole
Applies to: Envarsus XR (tacrolimus) and Vimovo (esomeprazole / naproxen)
Esomeprazole may significantly increase the blood levels of tacrolimus in some patients. This may increase the risk of serious side effects such as diabetes, infections, kidney problems, hyperkalemia (high blood levels of potassium), tremor, seizures, visual disturbances, high blood pressure, and heart enlargement. In addition, chronic use of drugs known as proton pump inhibitors including esomeprazole can sometimes cause hypomagnesemia (low blood levels of magnesium), and the risk may be further increased when combined with other medications that also have this effect such as tacrolimus. In severe cases, hypomagnesemia can lead to irregular heart rhythm, palpitations, muscle spasm, tremor, and seizures. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
naproxen esomeprazole
Applies to: Vimovo (esomeprazole / naproxen) and Vimovo (esomeprazole / naproxen)
Talk to your doctor before using naproxen together with esomeprazole. Using these medications together may affect the enteric coating of naproxen, causing the medication to be released too early in the body. This can make naproxen less effective. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
tacrolimus food
Applies to: Envarsus XR (tacrolimus)
Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.
esomeprazole food
Applies to: Vimovo (esomeprazole / naproxen)
Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one hour before meals and at the same time every day. When esomeprazole is given to patients receiving continuous enteral nutrition (tube feedings), the tube feeding should be interrupted for at least 1 hour before and 1 hour after the dose of esomeprazole. This will make it easier for your body to absorb the medication. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
naproxen food
Applies to: Vimovo (esomeprazole / naproxen)
Ask your doctor before using naproxen together with ethanol. Do not drink alcohol while taking naproxen. Alcohol can increase your risk of stomach bleeding caused by naproxen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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