Skip to main content

Drug Interactions between Effervescent Pain Relief and treosulfan

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

aspirin sodium bicarbonate

Applies to: Effervescent Pain Relief (aspirin/citric acid/sodium bicarbonate) and Effervescent Pain Relief (aspirin/citric acid/sodium bicarbonate)

Using sodium bicarbonate together with aspirin may decrease the effects of aspirin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

sodium bicarbonate treosulfan

Applies to: Effervescent Pain Relief (aspirin/citric acid/sodium bicarbonate) and treosulfan

Consumer information for this interaction is not currently available.

MONITOR: Parenteral hydration with sodium bicarbonate during treosulfan infusion has been related to an increase of skin disorders like rash and dermatitis. The mechanism of the interaction may be acceleration of the pH-dependent formation of alkylating epoxides. Also, this combination may induce bladder injury from activation of treosulfan in alkaline urine.

MANAGEMENT: Caution is advised when parenteral sodium bicarbonate is used during treosulfan infusion. Patients should be monitored for increased skin disorders such as rash and dermatitis, and for bladder injury. Some experts discourage the alkalinization of patients during treatment with treosulfan and recommend a split-dose or continuous IV infusion regimen of high-dose treosulfan to avoid risk of methanesulfonic acid induced acidosis.

Drug and food interactions

Moderate

aspirin food

Applies to: Effervescent Pain Relief (aspirin/citric acid/sodium bicarbonate)

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

aspirin food

Applies to: Effervescent Pain Relief (aspirin/citric acid/sodium bicarbonate)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer