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Drug Interactions between efavirenz and Kimyrsa

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

efavirenz oritavancin

Applies to: efavirenz and Kimyrsa (oritavancin)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of efavirenz, which is primarily metabolized by the isoenzyme.

MONITOR: Administration of efavirenz can cause central nervous system (CNS) toxicity. In controlled studies, patients receiving efavirenz reported central nervous system and psychiatric symptoms. These CNS toxicity symptoms included, but were not limited to, dizziness, impaired concentration, somnolence, abnormal dreams, insomnia, and hallucinations. Combining efavirenz with other centrally-acting CNS agents may add to the neurotoxic effects of efavirenz.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if efavirenz is prescribed in combination with CYP450 3A4 inducers. Close clinical and laboratory monitoring of antiretroviral response is recommended. Alternative treatment that do not affect efavirenz metabolism should be considered whenever possible. Additionally, Patients treated with any medication that can cause CNS toxicity symptoms should be advised to seek prompt medical attention if they experience symptoms. Patients should be advised to avoid driving, operating machinery, or engaging in potentially hazardous activities requiring mental alertness and motor coordination until they know how the medications affect them.

Drug and food interactions

Moderate

efavirenz food

Applies to: efavirenz

Taking efavirenz with food increases the amount of medicine in your body, which may increase the frequency of side effects. You should take efavirenz once a day on an empty stomach, preferably at bedtime. Taking it at bedtime may make some side effects such as dizziness, trouble sleeping, drowsiness, trouble concentrating, and/or unusual dreams less bothersome. However, these symptoms may be more severe if efavirenz is used with alcohol or mood-altering (street) drugs. You should avoid driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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