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Drug Interactions between doravirine / lamivudine / tenofovir disoproxil and rifabutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

rifabutin tenofovir

Applies to: rifabutin and doravirine / lamivudine / tenofovir disoproxil

Rifabutin may significantly reduce the blood levels of tenofovir from certain preparations, which may make it less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major

rifabutin doravirine

Applies to: rifabutin and doravirine / lamivudine / tenofovir disoproxil

Rifabutin may significantly reduce the blood levels of doravirine, which may make the medication less effective in treating HIV infection. Additionally, it may lead to development of viral resistance to this and various other HIV medications that are currently used for treatment. Doravirine should not be started until at least 4 weeks after discontinuing rifabutin. If they are used together, a dosage increase of doravirine is normally recommended. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Minor

tenofovir food

Applies to: doravirine / lamivudine / tenofovir disoproxil

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer