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Drug Interactions between disopyramide and Naropin SDV

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

disopyramide ROPivacaine

Applies to: disopyramide and Naropin SDV (ropivacaine)

Consumer information for this interaction is not currently available.

MONITOR: Amide-type local anesthetics (e.g., lidocaine, bupivacaine, ropivacaine) may have additive cardiac effects when coadministered with class I antiarrhythmic agents. In general, the toxic effects of amide-type anesthetics when coadministered with structurally related antiarrhythmic agents are additive and potentially synergistic which may lead to bradycardia, chest pain, heart block, arrhythmias, ECG abnormalities, and cardiac arrest. The clinical significance of the interaction has not been established.

MANAGEMENT: If coadministration of amide-type local anesthetics with class I antiarrhythmic agents (e.g., procainamide, mexiletine, disopyramide) is required, caution and clinical monitoring are recommended for additive cardiac effects. Advise patients to contact their physician if they experience adverse effects such as chest pain, palpitations, nausea, vomiting, lightheadedness, nervousness, dizziness, or tremors.

References

  1. "Product Information. Lidocaine Hydrochloride (lidocaine)." Hospira Healthcare Corporation (2015):
  2. "Product Information. Lidocaine Hydrochloride (lidocaine)." Hameln Pharma Ltd (2022):
  3. "Product Information. Xylocaine HCl (lidocaine)." Aspen Pharmacare Australia Pty Ltd (2022):

Drug and food interactions

Moderate

disopyramide food

Applies to: disopyramide

Grapefruit juice may increase the blood levels of certain medications such as disopyramide. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with disopyramide. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Switch to professional interaction data

Minor

disopyramide food

Applies to: disopyramide

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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