Drug Interactions between diroximel fumarate and Picot Plus

Using sodium bicarbonate together with aspirin may decrease the effects of aspirin. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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The use of diroximel fumarate in combination with higher doses of aspirin, such as those used to relieve pain and inflammation, may increase the potential for kidney damage. Let your doctor know if you experience any signs or symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and/or irregular heart rhythm. You can also speak with your healthcare provider to see if an alternative pain reliever, such as acetaminophen, might be an option for you.

Lower doses of non-enteric coated aspirin (up to 325 mg) are sometimes taken about 30 minutes prior to diroximel fumarate to help reduce the occurrence and severity of flushing. This combination has not been evaluated for longer than 4 weeks. Let your doctor know if you experience any side effects that are particularly bothersome or do not improve during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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