Drug Interactions between diroximel fumarate and Jesduvroq
This report displays the potential drug interactions for the following 2 drugs:
- diroximel fumarate
- Jesduvroq (daprodustat)
Interactions between your drugs
diroximel fumarate daprodustat
Applies to: diroximel fumarate and Jesduvroq (daprodustat)
Consumer information for this interaction is not currently available.
MONITOR: Coadministration of hypoxia-inducible factor prolyl hydroxylase (HIF PH) inhibitors, such as vadadustat or daprodustat, with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, were reported during vadadustat and daprodustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.
MANAGEMENT: Caution is advised if vadadustat or daprodustat are coadministered with drugs that have a known risk of gastrointestinal erosion, including but not limited to NSAIDs, corticosteroids, oral bisphosphonates, oral potassium formulations, anticoagulants as well as certain chemotherapeutic agents (e.g., kinase inhibitors) and antibiotics. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
Drug and food interactions
diroximel fumarate food
Applies to: diroximel fumarate
Taking diroximel fumarate with high-fat, high-calorie meals or snacks may reduce the levels of active medication in the blood, which may make the medication less effective in treating your condition. Food may help improve the tolerability of diroximel fumarate if you are experiencing flushing or gastrointestinal side effects from the medication; however, meals or snacks should contain no more than 700 calories and no more than 30 grams of fat. In addition, you should avoid or limit the use of alcohol while being treated with diroximel fumarate. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
daprodustat food
Applies to: Jesduvroq (daprodustat)
Using daprodustat while smoking or drinking alcohol may increase the risk of side effects in the gastrointestinal tract such as stomach inflammation and bleeding. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you have signs and symptoms of gastrointestinal bleeding such as abdominal pain, coughing up or vomiting fresh or dried blood that looks like coffee grounds, black, tarry stools, trouble swallowing, or chest or throat pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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