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Drug Interactions between dihydrocodeine / guaifenesin and nafcillin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nafcillin dihydrocodeine

Applies to: nafcillin and dihydrocodeine / guaifenesin

Nafcillin may reduce the blood levels of dihydrocodeine, which may make dihydrocodeine less effective in treating your condition. Additionally, if you have been receiving treatment with dihydrocodeine, adding nafcillin may cause you to experience unpleasant withdrawal symptoms such as excessive sweating, chills, flushing, restlessness, irritability, anxiety, tremor, rapid heartbeat and nausea. On the other hand, if you have been receiving both medications, suddenly discontinuing nafcillin may increase the blood levels of dihydrocodeine, which could increase or prolong its adverse effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

nafcillin food

Applies to: nafcillin

You may experience reduced absorption of nafcillin in the presence of food. The effectiveness of the antibiotic may be reduced. Nafcillin should be administered one hour before or two hours after meals. This will make it easier for your body to absorb the medication. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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