Can you take Digitoxin with Sodium zirconium cyclosilicate?
1 drug interaction and 6 additional warnings found for the following 2 drugs:
- digitoxin
- sodium zirconium cyclosilicate
Drug interactions
Moderate drug interactions
Moderate:
digitoxin sodium zirconium cyclosilicate
Applies to: digitoxin and sodium zirconium cyclosilicate
If sodium zirconium cyclosilicate lowers your blood potassium too much, it may increase the sensitivity of your heart to the effects of digitoxin.
You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
Let your doctor know if you experience:
- dizziness
- lightheadedness
- fainting
- constipation
- abdominal cramping
- confusion
- muscle weakness
- muscle cramps
- numbness or tingling
- a rapid heartbeat
These may be symptoms of low potassium levels.
You should seek immediate medical attention if you experience signs and symptoms that may indicate excessive effects of digitoxin, such as:
- nausea
- vomiting
- diarrhea
- loss of appetite
- visual disturbances (blurred vision; light halos around objects; green or yellow vision)
- a fast, slow, or irregular heartbeat
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
sodium zirconium cyclosilicate Food/Lifestyle
Applies to: sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference.
What to do: In general, other oral medications should be taken 2 hours before or 2 hours after you take sodium zirconium cyclosilicate unless otherwise directed by your doctor.
Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
5 potential interactions Applies to: 5 conditions, including Constipation, Heart Failure, Fluid Retention, Renal Dysfunction, and Gastrointestinal Obstruction.
Constipation
Major:
sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate has a major potential interaction with Constipation.
The use of sodium zirconium cyclosilicate should be avoided in patients with severe constipation, bowel obstruction or impaction, including abnormal postoperative bowel motility disorders. This medication has not been studied in patients with these conditions and may be ineffective and it may worsen gastrointestinal conditions.
Fluid Retention
Moderate:
sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate has a moderate potential interaction with Fluid Retention.
Each 5 g dose of sodium zirconium cyclosilicate contains approximately 400 mg of sodium, and can cause edema, which was generally mild to moderate in severity in clinical trials. Patients should be monitored for signs of edema, particularly those who should restrict their sodium intake or are prone to fluid overload (e.g., heart failure or renal disease). Advise patients to adjust dietary sodium, and if appropriate, increase the dose of diuretics as needed.
Gastrointestinal Obstruction
Major:
sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate has a major potential interaction with Gastrointestinal Obstruction.
The use of sodium zirconium cyclosilicate should be avoided in patients with severe constipation, bowel obstruction or impaction, including abnormal postoperative bowel motility disorders. This medication has not been studied in patients with these conditions and may be ineffective and it may worsen gastrointestinal conditions.
Heart Failure
Moderate:
sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate has a moderate potential interaction with Heart Failure.
Each 5 g dose of sodium zirconium cyclosilicate contains approximately 400 mg of sodium, and can cause edema, which was generally mild to moderate in severity in clinical trials. Patients should be monitored for signs of edema, particularly those who should restrict their sodium intake or are prone to fluid overload (e.g., heart failure or renal disease). Advise patients to adjust dietary sodium, and if appropriate, increase the dose of diuretics as needed.
Renal Dysfunction
Moderate:
sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate has a moderate potential interaction with Renal Dysfunction.
Each 5 g dose of sodium zirconium cyclosilicate contains approximately 400 mg of sodium, and can cause edema, which was generally mild to moderate in severity in clinical trials. Patients should be monitored for signs of edema, particularly those who should restrict their sodium intake or are prone to fluid overload (e.g., heart failure or renal disease). Advise patients to adjust dietary sodium, and if appropriate, increase the dose of diuretics as needed.
Report options
More resources
digitoxin
A total of 274 drugs are known to interact with digitoxin.
- Digitoxin is in the drug class inotropic agents.
sodium zirconium cyclosilicate
A total of 110 drugs are known to interact with sodium zirconium cyclosilicate.
- Sodium zirconium cyclosilicate is in the drug class cation exchange resins.
- Sodium zirconium cyclosilicate is used to treat Hyperkalemia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.