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Drug interactions between didanosine and tenofovir

Results for the following 2 drugs:
didanosine
tenofovir

Interactions between your drugs

Major

didanosine tenofovir

Applies to: didanosine and tenofovir

Talk to your doctor before using didanosine together with tenofovir. Combining these medications may increase the blood levels and effects of didanosine. This can increase the risk of serious side effects such as pancreatitis (inflammation of the pancreas), lactic acidosis (the buildup of lactic acid in the body), and peripheral neuropathy (nerve damage, particularly in the hands and feet). You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, abdominal pain, fatigue, weight loss, loss of appetite, shortness of breath, muscle weakness, or numbness, tingling, or pain in the hands and feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

didanosine food

Applies to: didanosine

Food decreases the levels of didanosine in your body. Take didanosine on an empty stomach at least 30 minutes before or 2 hours after a meal. This will make it easier for your body to absorb the medication. Do not crush, chew, break, or open a delayed-release capsule (Videx EC). Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

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Minor

tenofovir food

Applies to: tenofovir

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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