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Drug Interactions between dexbrompheniramine / pseudoephedrine and midodrine

This report displays the potential drug interactions for the following 2 drugs:

  • dexbrompheniramine/pseudoephedrine
  • midodrine

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Interactions between your drugs


pseudoephedrine midodrine

Applies to: dexbrompheniramine / pseudoephedrine and midodrine

Using midodrine together with pseudoephedrine can increase the risk of hypertension. Midodrine may cause significant increases in blood pressure by constricting the blood vessels, and the risk for complications may be increased when used with other drugs that also affect blood pressure such as decongestants, stimulants, and certain medications for headache, glaucoma, or eye redness relief. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor immediately if you experience symptoms that could indicate an acute increase in blood pressure, such as severe or throbbing headache, pounding in the ears, chest pain, and blurred vision. In some cases, sleeping with the head of the bed elevated or taking the last daily dose of midodrine 3 to 4 hours before bedtime may help lessen the effects on blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


dexbrompheniramine food

Applies to: dexbrompheniramine / pseudoephedrine

Alcohol can increase the nervous system side effects of dexbrompheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dexbrompheniramine. Do not use more than the recommended dose of dexbrompheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.