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Drug interactions between deutetrabenazine and tetrabenazine

Results for the following 2 drugs:

Interactions between your drugs


tetrabenazine deutetrabenazine

Applies to: tetrabenazine and deutetrabenazine

Using tetrabenazine together with deutetrabenazine is not recommended. These medications have similar effects and taking them together can increase the risk of serious side effects. You may start taking deutetrabenazine the day after stopping tetrabenazine at the dose prescribed by your doctor. Call your doctor if you experience depression, suicidal thoughts, anxiety, restlessness, excessive drowsiness, or symptoms of parkinsonism such as slight shaking, body stiffness, trouble moving or keeping your balance. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


tetrabenazine food

Applies to: tetrabenazine

Alcohol can increase the nervous system side effects of tetrabenazine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with tetrabenazine. Do not use more than the recommended dose of tetrabenazine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.


VMAT2 inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'VMAT2 inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'VMAT2 inhibitors' category:

  • deutetrabenazine
  • tetrabenazine

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.