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Drug Interactions between desmopressin and Pepto Diarrhea Control

This report displays the potential drug interactions for the following 2 drugs:

  • desmopressin
  • Pepto Diarrhea Control (loperamide)

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Interactions between your drugs


desmopressin loperamide

Applies to: desmopressin and Pepto Diarrhea Control (loperamide)

Loperamide can sometimes enhance the effects of desmopressin. Although not common, this may increase the risk of developing water retention and a condition known as hyponatremia, which is caused by an abnormal decrease in blood sodium concentration. In serious cases, hyponatremia can lead to seizure, coma, or even death. You should seek immediate medical attention if you experience loss of appetite, nausea, vomiting, drowsiness, fatigue, weakness, headache, confusion, difficulty concentrating, memory impairment, decreased urination, and/or sudden weight gain, as these may be early signs and symptoms of water intoxication and hyponatremia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


loperamide food

Applies to: Pepto Diarrhea Control (loperamide)

Alcohol can increase the nervous system side effects of loperamide such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with loperamide. Do not use more than the recommended dose of loperamide, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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desmopressin food

Applies to: desmopressin

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.