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Drug Interactions between desmopressin and methylprednisolone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

methylPREDNISolone desmopressin

Applies to: methylprednisolone and desmopressin

Using desmopressin together with methylPREDNISolone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood. In severe cases, hyponatremia can lead to seizures, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, and/or sudden weight gain, as these may be symptoms of water intoxication and hyponatremia. Early diagnosis and treatment are essential to help prevent progression to more serious and life-threatening complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

methylPREDNISolone food

Applies to: methylprednisolone

Grapefruit juice may increase the blood levels of certain medications such as methylPREDNISolone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with methylPREDNISolone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Minor

desmopressin food

Applies to: desmopressin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.