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Drug Interactions between conjugated estrogens topical and Veozah

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

conjugated estrogens topical fezolinetant

Applies to: conjugated estrogens topical and Veozah (fezolinetant)

Consumer information for this interaction is not currently available.

CONTRAINDICATED: Coadministration with inhibitors of CYP450 1A2 may significantly increase the plasma concentrations of fezolinetant, which is primarily metabolized by the isoenzyme. In clinical drug interaction studies, coadministration of the potent CYP450 1A2 inhibitor fluvoxamine increased the peak plasma concentration (Cmax) and systemic exposure (AUC) by 80% and 840%, respectively. Likewise, the moderate CYP450 1A2 inhibitor, mexiletine, is predicted through physiologically based pharmacokinetic (PBPK) modeling to increase the Cmax and AUC of fezolinetant by 40% and 360%, respectively. The weak CYP450 1A2 inhibitor cimetidine is also predicted via PBPK to increase the Cmax and AUC of fezolinetant by 30% and 100%, respectively.

MANAGEMENT: Concomitant use of fezolinetant with CYP450 1A2 inhibitors is considered contraindicated.

Drug and food interactions

Major

fezolinetant food

Applies to: Veozah (fezolinetant)

Consuming food or beverages that contain caffeine (e.G., chocolate, coffee, cola drinks, energy drinks, tea) is not recommended while taking fezolinetant. Caffeine may significantly increase the levels of fezolinetant in the blood. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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