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Drug interactions between Complera and omeprazole

Results for the following 2 drugs:
Complera (emtricitabine/rilpivirine/tenofovir)
omeprazole

Interactions between your drugs

Major

omeprazole rilpivirine

Applies to: omeprazole and Complera (emtricitabine / rilpivirine / tenofovir)

Using rilpivirine together with omeprazole is not recommended. By reducing the acidity level in the stomach, omeprazole can decrease the absorption and blood levels of rilpivirine and make the medication less effective against HIV. Talk to a healthcare provider if you have any questions or concerns. Your doctor or pharmacist may be able to recommend alternatives that do not interact (or interact to a lesser extent) if you require treatment for stomach acid or ulcer while you are being treated with rilpivirine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

rilpivirine food

Applies to: Complera (emtricitabine / rilpivirine / tenofovir)

Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine.

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Minor

tenofovir food

Applies to: Complera (emtricitabine / rilpivirine / tenofovir)

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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