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Drug Interactions between codeine / dexbrompheniramine / pseudoephedrine and hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

This report displays the potential drug interactions for the following 2 drugs:

  • codeine/dexbrompheniramine/pseudoephedrine
  • hyoscyamine/methenamine/methylene blue/phenyl salicylate/sodium biphosphate

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Interactions between your drugs

Major

codeine methylene blue

Applies to: codeine / dexbrompheniramine / pseudoephedrine and hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

Using codeine together with methylene blue may rarely increase the risk of serious side effects such as respiratory depression, low blood pressure, fainting, coma, and even death. In general, it is best to wait at least 14 days after stopping methylene blue before you start treatment with codeine. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should avoid the use of alcohol while being treated with these medications. Also avoid driving or operating hazardous machinery until you know how your medications affect you, and do not exceed the dosage or frequency of use prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

pseudoephedrine methylene blue

Applies to: codeine / dexbrompheniramine / pseudoephedrine and hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

Using methylene blue together with pseudoephedrine is not recommended. Combining these medications can cause dangerously high blood pressure and even death. You may use pseudoephedrine only after you have been off methylene blue for at least 14 days. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting during treatment with methylene blue, as these may be signs and symptoms of excessively high blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

codeine hyoscyamine

Applies to: codeine / dexbrompheniramine / pseudoephedrine and hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

Using codeine together with hyoscyamine can increase the effects of either medication. This can commonly cause dizziness, drowsiness, difficulty concentrating, dry mouth, abdominal cramping, and constipation. Some people may also experience some impairment in thinking and judgment. Avoid driving or operating hazardous machinery until you know how the medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

codeine sodium biphosphate

Applies to: codeine / dexbrompheniramine / pseudoephedrine and hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

Codeine can occasionally cause seizures, especially if you are elderly, alcoholic, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system like a brain tumor or head trauma. The risk is also increased if you have low blood levels of electrolytes such as calcium, magnesium, potassium or sodium, which can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect. You should use sodium biphosphate exactly as prescribed by your doctor, and drink plenty of clear liquids before, during, and after the cleansing process to avoid becoming dehydrated. Your doctor may be able to recommend specific fluids you can drink before starting sodium biphosphate to help maintain your electrolyte levels. Contact your doctor if you experience signs and symptoms of low electrolyte levels such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

hyoscyamine dexbrompheniramine

Applies to: hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate and codeine / dexbrompheniramine / pseudoephedrine

Using hyoscyamine together with dexbrompheniramine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to occur in the elderly or those with a debilitating condition. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

sodium biphosphate food

Applies to: hyoscyamine / methenamine / methylene blue / phenyl salicylate / sodium biphosphate

Oral medications may not be properly absorbed when they are taken within one hour before starting sodium biphosphate for bowel cleansing. Talk to your doctor or pharmacist to see if you should adjust the dosing schedule of your other medications before you begin bowel cleansing treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

dexbrompheniramine food

Applies to: codeine / dexbrompheniramine / pseudoephedrine

Alcohol can increase the nervous system side effects of dexbrompheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dexbrompheniramine. Do not use more than the recommended dose of dexbrompheniramine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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