Drug Interactions between clonidine / ketorolac / ropivacaine and morphine liposomal

CloNIDine and morphine liposomal may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ROPivacaine may increase the levels of morphine liposomal when both are given by epidural injection within a short period of time of each other. Because these medications are generally given in the hospital, your doctor/surgeon will likely take precautions to minimize the interaction, such as flushing the catheter after injecting the dose of ROPivacaine and waiting at least 15 to 30 minutes before giving you morphine liposomal. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.