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Drug Interactions between clarithromycin and progesterone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs


clarithromycin progesterone

Applies to: clarithromycin and progesterone

Clarithromycin may increase the blood levels and effects of progesterone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects, such as changes in weight and/or appetite, dizziness, headaches, upset stomach, nausea, vomiting, bloating, and/or bleeding between menstrual cycles. Seek immediate medical care if you experience any of the following, as they could indicate that you are experiencing a serious side effect: dark urine; light-colored stools; yellow skin or eyes; very bad headache or dizziness; passing out; change in eyesight or a change in how contact lenses feel; severe upset stomach; severe vomiting; pain in the upper right belly area, right shoulder area, or between the shoulder blades; chest pain or pressure; coughing up blood; trouble breathing; swelling, warmth, numbness, change of color or pain in a leg or arm; trouble speaking or swallowing; depression or other mood changes; a lump in the breast; breast pain or soreness; nipple discharge; bone pain; and/or muscle cramps or spasms.

On the other hand, antibiotics such as clarithromycin can also reduce the amount of estrogen available in the body from estrogen containing hormonal medications. If you are using an estrogen containing medication for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. Be sure to alert your doctor if you are having any vomiting and/or diarrhea as this too can impact how well your hormonal birth control works. Talk to your doctor or pharmacist to determine if you should use an alternative or additional form of birth control during or after treatment with clarithromycin. If you are using an estrogen containing medication for a purpose other than birth control, discuss any questions you may have or any changes you notice regarding how well your medication is working with your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


progesterone food

Applies to: progesterone

Grapefruit juice may increase the blood levels of certain medications such as progesterone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with progesterone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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clarithromycin food

Applies to: clarithromycin

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.