Can you take Cisapride with Treosulfan?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- cisapride
- treosulfan
Drug interactions
Major drug interactions
Major:
cisapride treosulfan
Applies to: cisapride and treosulfan
Using cisapride together with treosulfan is not recommended. Combining these medications may significantly increase the blood levels of cisapride. High blood levels of cisapride can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with cisapride. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
**Cisapride (Propulsid) is no longer marketed in the United States. You should only be taking cisapride if you are obtaining the medication from your doctor though a Limited Access Program developed jointly by the manufacturer and the FDA.**
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
cisapride Food/Lifestyle
Applies to: cisapride
Cisapride is no longer on the market in the US. Do not take cisapride with any other medication, food, or beverage.
**Cisapride (Propulsid) is no longer marketed in the United States. You should only be taking cisapride if you are obtaining the medication from your doctor though a Limited Access Program developed jointly by the manufacturer and the FDA.**
Disease interactions
7 potential interactions Applies to: 7 conditions, including Seizures, Liver Disease, Cardiovascular Conditions and Disorders, Renal Dysfunction, and Gastrointestinal Perforation.
Cardiovascular Conditions and Disorders
Major:
cisapride
Cisapride has a major potential interaction with Cardiovascular Conditions and Disorders.
The use of cisapride is contraindicated in patients with cardiac disease. Serious cardiac arrhythmias, including ventricular arrhythmias and torsades de pointes associated with QT prolongation have been rarely associated with the use of cisapride, especially when taken in conjunction with other medications known to prolong the QT interval.
Gastrointestinal Hemorrhage
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Hemorrhage.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Gastrointestinal Obstruction
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Obstruction.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Gastrointestinal Perforation
Major:
cisapride
Cisapride has a major potential interaction with Gastrointestinal Perforation.
The use of cisapride is contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Enhanced gastrointestinal motility could be harmful in these patients.
Liver Disease
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Liver Disease.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Renal Dysfunction
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Renal Dysfunction.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Seizures
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Seizures.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
Report options
More resources
cisapride
A total of 420 drugs are known to interact with cisapride.
- Cisapride is in the drug class GI stimulants.
- Cisapride is used to treat the following conditions:
treosulfan
A total of 547 drugs are known to interact with treosulfan.
- Treosulfan is in the drug class alkylating agents.
- Treosulfan is used to treat Stem Cell Transplant Conditioning.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.