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Drug Interactions between cinacalcet and Xgeva

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cinacalcet denosumab

Applies to: cinacalcet and Xgeva (denosumab)

Using denosumab together with cinacalcet may significantly decrease the calcium levels in your blood. Contact your doctor if your condition changes or if you experience symptoms of hypocalcemia (low blood calcium) such as numbness or tingling around your mouth, uncontrolled muscle movements, irritability, depression, irregular heartbeats, or any increased sensitivity. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

cinacalcet food

Applies to: cinacalcet

Food can enhance the levels of cinacalcet in your body. Cinacalcet should be taken just after eating food. Do not take it on an empty stomach. This will make it easier for your body to absorb the medication. Do not crush, chew, or break the tablets. Swallow them whole.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer