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Drug Interactions between cimetidine and Lidotran

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cimetidine lidocaine topical

Applies to: cimetidine and Lidotran (lidocaine topical)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with cimetidine may increase the plasma concentration of topical lidocaine formulations. In a study of healthy volunteers, cimetidine increased the systemic exposure (AUC) of a 10% topical lidocaine spray applied to the pharynx by 1.5-fold. The proposed mechanism for this interaction is cimetidine-mediated inhibition of CYP450 1A2 and 3A4 which are involved in the metabolism of lidocaine. The degree of systemic absorption of topical lidocaine may be dependent on the duration of application and the applied surface area.

MANAGEMENT: The potential for an interaction should be considered during concomitant use of cimetidine and topical lidocaine formulations. If coadministration is required, patients should be monitored for lidocaine-related adverse effects or toxicities including drowsiness, mental status change, or tremor.

Drug and food interactions

Minor

cimetidine food

Applies to: cimetidine

Information for this minor interaction is available on the professional version.

Minor

cimetidine food

Applies to: cimetidine

Information for this minor interaction is available on the professional version.

Minor

cimetidine food

Applies to: cimetidine

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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