Drug Interactions between choline salicylate / magnesium salicylate and patiromer

Using choline salicylate together with magnesium salicylate is generally not recommended. Combining these medications may increase the risk of side effects in the gastrointestinal tract such as inflammation, pain, bleeding, and ulceration. Bruising and other bleeding complications may also occur. You should take these medications with food to lessen gastrointestinal side effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Patiromer can bind to calcium, iron, magnesium, and other minerals in the gastrointestinal tract. This may inactivate both patiromer and the mineral it binds to and reduce the effectiveness of both medications. To avoid or minimize the interaction, the dosing times of patiromer and magnesium salicylate should be separated by several hours. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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