Drug Interactions between cholestyramine and moxifloxacin / triamcinolone

Moxifloxacin and other medications in its class can cause tendinitis and tendon rupture, and the risk may be increased when combined with a steroid such as triamcinolone. Older adults over 60 years of age and those who have received a kidney, heart, and/or lung transplant may be particularly susceptible. Tendon rupture can occur during or up to several months after finishing moxifloxacin treatment and may require surgery or result in prolonged disability. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Stop taking moxifloxacin and call your doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. You should also avoid exercise or use of the affected area until further instruction from your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Bile acid binding resins such as cholestyramine, colestipol, and colesevelam may interfere with the absorption of triamcinolone and reduce its levels in the bloodstream. This may make the medication less effective in treating your condition. To minimize the possibility of interaction, it is recommended that you separate the dosing times of the bile acid binding resin and other oral medications. If you are taking cholestyramine or colestipol, you should take triamcinolone at least 1 hour before or 4 to 6 hours after the cholestyramine or colestipol dose. If you are taking colesevelam, you should take triamcinolone at least 4 hours before the colesevelam dose, or separate the dosing times by as much as possible if a 4 hour interval is not achievable. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.