Skip to main content

Drug Interactions between chlorpromazine and Synalgos-DC

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Major

chlorproMAZINE dihydrocodeine

Applies to: chlorpromazine and Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Using narcotic pain or cough medications together with other medications that also cause central nervous system depression such as chlorproMAZINE can lead to serious side effects including respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, because these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you.

Using narcotic pain or cough medications together with chlorproMAZINE may also increase the risk of constipation. Severe complications may include intestinal obstruction, fecal impaction, or other serious and even life-threatening injuries to the bowel that may require hospitalization or surgery. You should maintain adequate hydration, physical activity, and fiber intake during treatment with these medications to help prevent constipation. Talk to your healthcare provider to see if taking a laxative prophylactically may be appropriate for you. Seek immediate medical attention if you experience signs and symptoms of constipation such as difficulty passing stool, incomplete passage of stool, hard or dry stool, and decreased bowel movement frequency (especially if less than three times a week), or if you have symptoms that could indicate more serious gastrointestinal problems such as nausea, vomiting, bloating, and abdominal pain or swelling. Prompt treatment with appropriate laxatives and other measures are essential to minimize the risk of complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

aspirin caffeine

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine) and Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Moderate

chlorproMAZINE food

Applies to: chlorpromazine

Ask your doctor before using chlorproMAZINE together with ethanol (alcohol). This can cause uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature. Use caution when driving, operating machinery, or performing other hazardous activities, these medicaions may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

aspirin food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

chlorproMAZINE food

Applies to: chlorpromazine

Consumer information for this interaction is not currently available.

MONITOR: Smoking cessation may lead to elevated plasma concentrations and enhanced pharmacologic effects of drugs that are substrates of CYP450 1A2 (and possibly CYP450 1A1) and/or certain drugs with a narrow therapeutic index (e.g., flecainide, pentazocine). One proposed mechanism is related to the loss of CYP450 1A2 and 1A1 induction by polycyclic aromatic hydrocarbons in tobacco smoke; when smoking cessation agents are initiated and smoking stops, the metabolism of certain drugs may decrease leading to increased plasma concentrations. The mechanism by which smoking cessation affects narrow therapeutic index drugs that are not known substrates of CYP450 1A2 or 1A1 is unknown. The clinical significance of this interaction is unknown as clinical data are lacking.

MANAGEMENT: Until more information is available, caution is advisable if smoking cessation agents are used concomitantly with drugs that are substrates of CYP450 1A2 or 1A1 and/or those with a narrow therapeutic range. Patients receiving smoking cessation agents may require periodic dose adjustments and closer clinical and laboratory monitoring of medications that are substrates of CYP450 1A2 or 1A1.

Minor

caffeine food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Minor

aspirin food

Applies to: Synalgos-DC (aspirin / caffeine / dihydrocodeine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer