Drug interactions between chloroquine and hydroxychloroquine
Interactions between your drugs
chloroquine ↔ hydroxychloroquine
Applies to:chloroquine and hydroxychloroquine
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Hydroxychloroquine can cause prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Coadministration of hydroxychloroquine with other drugs that can prolong the QT interval should generally be avoided. Patients treated with hydroxychloroquine should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
- "Product Information. Plaquenil (R). (hydroxychloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Drug Interaction Classification
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.