Drug Interactions between chloramphenicol / hydrocortisone / polymyxin b ophthalmic and idelalisib

After using chloramphenicol ophthalmic, some of the medication may be absorbed into the bloodstream and may increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. Using chloramphenicol ophthalmic together with idelalisib may further increase those risks. You may be more likely to develop anemia, bleeding problems or infections due to low blood cell counts. Although serious side effects are not very common with medications administered to the eyes, ears, or vagina because only limited amounts of the medication generally get absorbed into the bloodstream, they can sometimes occur. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring to safely use both medications. You should seek medical attention if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Idelalisib may increase the blood levels of hydrocortisone ophthalmic. You may be more likely to experience side effects such as swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Children may experience a reduced growth rate due to excessive effects of hydrocortisone ophthalmic. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.