Drug Interactions between ceritinib and Prograf

Ceritinib may significantly increase the blood levels of tacrolimus. This may increase the risk of serious side effects such as infections, lymphoma and other cancers, diabetes, kidney problems, nervous system disorders (mental status changes, seizures, visual disturbances, tremors, abnormal sensations such as burning, pricking, tingling or numbness), high blood pressure, heart problems (myocardial hypertrophy, irregular heart rhythm), and high blood levels of potassium. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. You should also seek medical attention if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, muscle cramps, tiredness, weakness, dizziness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be signs and symptoms of kidney problems or hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.