Drug Interactions between celecoxib and zanubrutinib

Consumer information for this interaction is not currently available.

MONITOR CLOSELY: Coadministration of zanubrutinib and drugs that interfere with platelet function or coagulation may potentiate the risk of bleeding complications. Serious and fatal hemorrhagic events have been reported during zanubrutinib therapy. Grade 3 or higher bleeding events including intracranial and gastrointestinal hemorrhage, hematuria, and hemothorax have been reported in up to 4% of patients treated with zanubrutinib monotherapy, with fatalities occurring in 0.3% of patients. Overall, bleeding events of any grade, including purpura and petechiae, occurred in nearly 55% of patients, both with and without concomitant antiplatelet or anticoagulation therapy. The mechanism for the bleeding events is not well understood, although treatment with zanubrutinib commonly causes thrombocytopenia. Grade 3 or 4 thrombocytopenia was reported in up to 11.5% of patients treated with zanubrutinib monotherapy.

MANAGEMENT: Concomitant use of zanubrutinib in patients receiving other medications that interfere with platelet function or coagulation should be approached with caution. Close clinical and laboratory monitoring for bleeding complications is recommended during therapy. Patients should be advised to promptly report any signs and symptoms of bleeding to their physician. Discontinue zanubrutinib if intracranial hemorrhage of any grade occurs. Refer to the product labeling for dose adjustment or discontinuation of therapy recommendations if Grade 3 or higher adverse reactions occur.